期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 31, 页码 8468-8475出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b02598
关键词
polyporaceae; secondary metabolites; basidiomycota; structure elucidation
资金
- ASAFEM Project under the ERAfrica Programme of the European Commission [IC 070]
- German Academic Exchange Service (DAAD)
- Kenya National Council for Science and Technology (NACOSTI)
- China Scholarship Council (CSC)
Fermentation of the fungal strain Skeletocutis sp. originating from Mount Elgon Natural Reserve in Kenya, followed by bioassay guided fractionation led to the isolation of 12 previously undescribed metabolites named skeletocutins A-L (1-5 and 7-13) together with the known tyromycin A (6). Their structures were assigned by NMR spectroscopy complemented by HR-ESIMS. Compounds 1-6 and 11-13 exhibited selective activities against Gram-positive bacteria, while compound 10 weakly inhibited the formation of biofilm of Staphylococcus aureus. The isolated metabolites were also evaluated for inhibition of L-leucine aminopeptidase, since tyromycin A had previously been reported to possess such activities but only showed weak effects. Furthermore, all compounds were tested for antiviral activity against Hepatitis C virus (HCV), and compound 6 moderately inhibited HCV infectivity with an IC50 of 6.6 mu M.
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