期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 33, 页码 9382-9389出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b02391
关键词
TiO2 NPs; intestinal inflammation; gut flora; immune response
资金
- National Natural Science Foundation of China [81573161, 81803269, 81630086]
- Shanghai Municipality Health Commission [2017YQ0059]
- Shanghai Sailing Program [18YF1412100]
- Major Science and Technology Innovation Program of Shanghai Municipal Education Commission [2018YFC1705103]
- Shanghai Jiao Tong University [YG2017MS85]
Early stage exposure of foodborne substances, such as brightening agent titanium dioxide nanoparticles (TiO2 NPs), can cause long-term effects in adulthood. We aimed to explore the potential adverse effect of long-term dietary intake of TiO2 NPs. After feeding for 2-3 months from weaning, TiO2 NPs-exposed mice showed lower body weight and induced intestinal inflammation. However, this phenomenon was not observed in gut microbiota-removed mice. TiO2 NPs exposure rarely affected the diversity of microbial communities, but significantly decreased the abundance of several probiotic taxa including Bifidobacterium and Lactobacillus. Additionally, TiO2 NPs aggravated DSS-induced chronic colitis and immune response in vivo, and reduced the population of CD4+T cells, regulatory T cells, and macrophages in mesenteric lymph nodes. Therefore, dietary TiO2 NPs could interfere with the balance of immune system and dynamic of gut microbiome, which may result in low-grade intestinal inflammation and aggravated immunological response to external stimulus, thus introducing potential health risk.
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