期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 38, 期 6, 页码 249-266出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08830185.2019.1645138
关键词
Lipid metabolism; cytokine; fatty acid; obesity; atherosclerosis; steatohepatitis
类别
资金
- Project of Key issues of Tianjin Municipal Education Commission [2016YD01]
Adipose tissue has been considered as a crucial source of certain pro-inflammatory cytokines; conversely, these pro-inflammatory cytokines are involved in regulating the proliferation and apoptosis of adipocytes, promoting lipolysis, inhibiting lipid synthesis and decreasing blood lipids, etc. In recent decades, extensive studies have indicated that pro-inflammatory cytokines play important roles in the development of lipid metabolism of metabolic diseases, including obesity, atherosclerosis, steatohepatitis and hyperlipoproteinemia. However, the involved pro-inflammatory cytokines types and the underlying mechanisms remain largely unknown. The re-discovery of cancer as a metabolic disorder largely occurred in the last five years. Although pro-inflammatory cytokines have been intensively investigated in cancer research, there are very few studies about the roles of pro-inflammatory cytokines in the lipid metabolism of cancer. In the current review, we provide an overview of the progress that has been made in the roles of different pro-inflammatory cytokines in lipid metabolism of metabolic diseases including cancer.
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