期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 565, 期 -, 页码 50-58出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2019.04.065
关键词
Oxaliplatin; Hyaluronic acid; Carboxymethyl cellulose sodium; Hydrogel; Intra-abdominal anti-adhesion barrier; Colorectal cancer
资金
- Yonsei University College of Medicine [6-2017-0091]
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT & Future Planning, Republic of Korea [NRF-2017R1A2B2011520, NRF-2017R1D1A1B03031213, University-Centered Labs-2018R1A6A1A03023718]
Colorectal cancer (CRC) is the third most commonly diagnosed cancer among both men and women worldwide. New therapeutic strategies involving cytoreductive surgery and intra-peritoneal chemotherapy could lead to a definitive cure in some cases. However, postoperative intra-abdominal adhesion can cause further complications. In this study, hyaluronic acid (HA)- and carboxymethyl cellulose sodium (CMCNa)-based novel cross-linked hydrogels (HC hydrogels) were synthesized and fully characterized. We demonstrated that varied compositions of HA and CMCNa altered the microstructure, rheology, and degradation behavior of hydrogels. Pre-constructed hydrogels were further loaded with oxaliplatin to prevent intra-abdominal adhesion following chemotherapy. Sustained release of oxaliplatin was observed from hydrogels compared that from solutions, which release drugs through diffusion, following the Higuchi and Korsmeyer-Peppas models. Moreover, low adhesion scores in an in vivo SD rat model demonstrated inhibition of intra-peritoneal adhesion in response to HC hydrogels. Therefore, HC hydrogels offer a novel formulation strategy for providing an intra-abdominal anti-adhesion barrier after cytoreductive surgery and intra-peritoneal chemotherapy for CRC treatment.
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