期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms20153723
关键词
periodontitis; neuropsychiatric disorders; Alzheimer's disease; Parkinson's disease; major depression; schizophrenia; neuroinflammation; microglia
资金
- JSPS KAKENHI [19K08018, 17K09194, 19K08046]
- Grants-in-Aid for Scientific Research [19K08046, 17K09194, 19K08018] Funding Source: KAKEN
Increasing evidence implies a possible causal link between periodontitis and neuropsychiatric disorders, such as Alzheimer's disease (AD) and major depression (MD). A possible mechanism underlying such a link can be explained by neuroinflammation induced by chronic systemic inflammation. This review article focuses on an overview of the biological and epidemiological evidence for a feasible causal link of periodontitis to neuropsychiatric disorders, including AD, MD, Parkinson's disease, and schizophrenia, as well as the neurological event, ischemic stroke. If there is such a link, a broad spectrum of neuropsychiatric disorders associated with neuroinflammation could be preventable and modifiable by simple daily dealings for oral hygiene. However, the notion that periodontitis is a risk factor for neuropsychiatric disorders remains to be effectively substantiated.
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