The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of PreeclampsiaReview

Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound aetiology. It affects 3-6% of expecting mothers worldwide and it persists as a leading cause of maternal and foetal morbidity and mortality. In fact, hallmark features of preeclampsia (PE) result from vessel involvement and demonstrate maternal endothelium as a target tissue. Growing evidence suggests that chronic placental hypoperfusion triggers the production and release of certain agents that are responsible for endothelial activation and injury. In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homocysteine in the etiopathogenesis of preeclampsia and their possible clinical implications.