期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms20122897
关键词
allergic airway inflammation; mast cells; leukotriene B-4 receptor-2; asthma
资金
- Bio and Medical Technology Development Program through the National Research Foundation (NRF) - Ministry of Science, Information and Communication Technologies (ICT), and Future Planning, Republic of Korea [2017M3A9D8063317, 2017R1A2B4002203]
- BK21 Plus Program (College of Life Sciences and Biotechnology, Korea University)
- Korea University Grant
- National Research Foundation of Korea [2017R1A2B4002203] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Mast cells are effector cells in the immune system that play an important role in the allergic airway inflammation. Recently, it was reported that BLT2, a low-affinity leukotriene (LT) B-4 receptor, plays a pivotal role in the pathogenesis of allergic airway inflammation through its action in mast cells. We observed that highly elevated expression levels of BLT2 are critical for the pathogenesis leading to allergic airway inflammation, and that if BLT2 expression is downregulated by siBLT2-mediated knockdown, allergic inflammation is dramatically alleviated. Furthermore, we demonstrated that BLT2 mediates the synthesis of vascular endothelial growth factor (VEGF) and Th2 cytokines, such as interleukin (IL)-13, in mast cells during allergic inflammation. Based on the critical roles of BLT2 in mast cells in allergic inflammation, anti-BLT2 strategies could contribute to the development of new therapies for allergic airway inflammation.
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