期刊
APPLIED PHYSICS LETTERS
卷 108, 期 10, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4943369
关键词
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资金
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [NRF-2014R1A1A2059612]
- Technology Innovation Program - Ministry of Trade, Industry, and Energy (MOTIE) of Korea [10052749]
- NSF [DMR 1120187]
- AFOSR [FA9550-14-C-0001]
- National Research Foundation of Korea [2014R1A1A2059612] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We demonstrate a photoacoustic lens with a low f-number of 0.61 and a high focal gain of 220 at 15-MHz frequency for laser-generated focused ultrasound (LGFU), which enables free-field micro-cavitation in water. Due to tight ultrasonic focusing (90 mu m in lateral and 200 mu m in longitudinal spot widths at a distance of 9.2 mm), the lens produces a peak pressure of 20 MPa (positive) using an input laser energy of only 1 mJ/pulse (6-ns temporal width). Remarkably, we confirm single-pulsed micro-cavitation in a free-field condition by using this lens, which has not previously been achieved with LGFU. The free-field cavitation was monitored and characterized in terms of a bubble radius, a lifetime, and a probability. Our result demonstrates that LGFU amplitudes can be sufficiently higher than a threshold for free-field cavitation at a microscale spot, which is a crucial step for cavitation-based therapy with high precision. (C) 2016 AIP Publishing LLC.
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