期刊
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
卷 24, 期 10, 页码 1171-1181出版社
SPRINGER JAPAN KK
DOI: 10.1007/s10147-019-01490-2
关键词
Drug reactions; Melanoma; Immune checkpoint inhibitor; PD-1; CTLA-4; Sarcoidosis-like granuloma
类别
资金
- Chuck Fowler Foundation [RES119774]
Immune checkpoint inhibitors targeting the cytotoxic T lymphocyte-associated antigen-4 and programmed cell death-1 receptors have transformed the treatment of melanoma and other cancers. These therapies are associated with a number of side effects, including immune-related adverse events. Sarcoidosis-like granulomas (SLGs) are important immune checkpoint inhibitor-related reactions to recognize as SLGs can mimic disease progression and accordingly impact treatment decisions. We systematically review reports of immune checkpoint inhibitor-induced SLGs in cancer patients and discuss potential underlying pathophysiological mechanisms.
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