期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 132, 期 -, 页码 1-8出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.03.194
关键词
Inflammation; Periodontal disease; Periodontitis; Carbohydrates; Steatosis
资金
- Federal University of Piaui [PIBIC 2016/2017]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
Sulfated polysaccharides (PLS) extracted from the marine algae of the genus Gracilaria showed biological activity in different inflammatory models, except for periodontitis. Thus, this study aimed to evaluate the effectiveness of the treatment with PLS from Gracilaria caudata in ligature-induced periodontitis. 40 animals distributed into 5 groups were used (the control group (unligated), the ligated untreated group, and the ligated groups treated with 2.5, 5.0 and 10.0 mg/kg of PLS with intraperitoneal injection, respectively). After 20 days of treatment, the animals were killed and the following parameters were evaluated: Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD), Myeloperoxidase (MPO) activity, Alveolar Bone Loss (ABL) for periodontal tissues; histopathological examination of gingival and liver tissues (Steatosis score); glutathione and malondialdehyde concentrations in the liver, serum levels of alanine aminotransferase and aspartate aminotransferase. The data revealed that treatment with 2.5 mg/kg of PLS showed the best anti-inflammatory effects with reduction of GB!, PPD and MPO activity, as well as oxidative stress and steatosis in liver. Our results indicated that the adjunct treatment with PLS from Gracilaria caudata could prevent the periodontal and hepatic tissue alteration caused by periodontitis. (C) 2019 Elsevier B.V. All rights reserved.
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