期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 130, 期 -, 页码 34-49出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.02.094
关键词
Oral delivery; Gastrointestinal barriers; Transport pathways; Polysaccharides; Targeting; Bioavailability
Oral chemotherapy is the most preferred drug administration method due to non-invasive administration, more convenient, low healthcare cost, and patient compliance in comparison to intravenous chemotherapy. However, oral chemotherapy poses numerous hurdles to drug absorption through the gastrointestinal tract. Recently, nanocarriers have been extensively used for delivering anticancer drugs orally. Nanocarriers present distinctive advantages that comprise aiding drug dissolution owing to high surface to volume ratio, surface modifiability, protecting drugs from the harsh gastrointestinal environments and other features, all of which contribute to enhanced drugs bioavailability. Nanocarriers based on polysaccharides have emerged as the favored choice owing to their low/non-toxicity, biodegradability, and biocompatibility. In the last decade, the research on oral delivery of anticancer drug using polysaccharide nanocarrier has diversified in many fields. Yet there is no report that summaries these advances. This article aims to bridge that lacuna. In this review article, we have discussed the problems associated with oral chemotherapy and conquer these through polysaccharide nanocarriers. This review also provides a general idea on the current developments in polysaccharide nanocarrier for oral bioavailability enhancement of anticancer drugs. (C) 2019 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据