期刊
BIOMEDICAL CHROMATOGRAPHY
卷 29, 期 8, 页码 1267-1273出版社
WILEY
DOI: 10.1002/bmc.3416
关键词
multiple-template surface molecularly imprinted polymer; solid-phase extraction; estrogen; quinolone; simultaneous analysis
类别
资金
- National Natural Science Foundation of China [81173025, 21445007]
- Fundamental Research Funds for the Central Universities [GK: 201402049]
A novel multiple-template surface molecularly imprinted polymer (MTMIP) was synthesized using ofloxacin and 17-estradiol as templates and modified monodispersed poly(glycidylmethacrylate-co-ethylene dimethacrylate) (P-GMA/EDMA) beads as the support material. Static adsorption, solid-phase extraction and high-performance liquid chromatography were performed to investigate the adsorption properties and selective recognition characteristics of the polymer templates and their structural analogs. The maximum binding capacities of ofloxacin and 17-estradiol on the MTMIP were 9.0 and 6.6mg/g, respectively. Compared with the corresponding nonimprinted polymer, the MTMIP exhibited a much higher adsorption performance and selectivity toward three quinolones and three estrogens, which are common drug residues in food. The MTMIP served as a simple and effective pretreatment method and could be successfully applied to the simultaneous analysis of multiple target components in complex samples. Furthermore, the MTMIP may find useful applications as a solid-phase absorbent in the simultaneous determination of trace quinolones and estrogens in milk samples, as the recoveries were in the range 77.6-98.0%. Copyright (c) 2015 John Wiley & Sons, Ltd.
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