期刊
GENES & DEVELOPMENT
卷 33, 期 13-14, 页码 741-746出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.326363.119
关键词
box C/D small nucleolar RNA; small Cajal body RNA; 2 '-O-methylation; tRNA-derived fragment; angiogenin
资金
- l'Agence National de la Recherche [ANR-18-CE12-0008-01]
- Agence Nationale de la Recherche (ANR) [ANR-18-CE12-0008] Funding Source: Agence Nationale de la Recherche (ANR)
Site-specific 2'-O-ribose methylation of mammalian rRNAs and RNA polymerase II-synthesized spliceosomal small nuclear RNAs (snRNAs) is mediated by small nucleolar and small Cajal body (CB)-specific box C/D ribonucleoprotein particles (RNPs) in the nucleolus and the nucleoplasmic CBs, respectively. Here, we demonstrate that 2'-O-methylation of the C34 wobble cytidine of human elongator tRNA(Met)(CAT) is achieved by collaboration of a nucleolar and a CB-specific box C/D RNP carrying the SNORD97 and SCARNA97 box C/D 2'-O-methylation guide RNAs. Methylation of C34 prevents site-specific cleavage of tRNA(Met)(CAT) by the stress-induced endoribonuclease angiogenin, implicating box C/D guide RNPs in controlling stress-responsive production of putative regulatory tRNA fragments.
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