期刊
FUTURE MEDICINAL CHEMISTRY
卷 11, 期 14, 页码 1777-1790出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2018-0347
关键词
biomaterials; hydrogels; imaging; regenerative medicine; stem cells; translational therapy
资金
- National Key R&D Program of China [2017YFA0103200]
- National Natural Science Foundation of China [81671734]
- Key Projects of Tianjin and Technology Support Program [18YFZCSY00010]
Stem cell therapy is a promising alternative approach to the treatment of a number of incurable degenerative diseases. However, low cell retention and survival after transplantation limit the therapeutic efficacy of stem cells for clinical translational applications. The utilization of biomaterials has been progressively successful in controlling the fate of transplanted cells by imitating the cellular microenvironment for optimal tissue repair and regeneration. This review mainly focuses on the engineered microenvironments with synthetic biomaterials in modification of stem cell behaviors. Moreover, the possible advancements in translational therapy by using biomaterials with stem cells are prospected and the challenges of the current restriction in clinical applications are highlighted.
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