期刊
FUTURE MEDICINAL CHEMISTRY
卷 11, 期 10, 页码 1225-1236出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2018-0417
关键词
exosome; manufacturing; production
Exosomes are secreted by mammalian cells and are widely distributed in cellular systems. They are a medium of information and material transmission. The complexity of exosome nature and function is not thoroughly understood. Nevertheless, they are being confirmed as mediators of intercellular communication and play significant roles in many physiological and pathological processes. Significant obstacles to the efficient and robust isolation of large quantities of pure and specific exosomes still exist. These include a lack of understanding of the relationship between exosome characteristics and function, and a shortage of scalable solutions to separate specific exosomes from other large entities remain. Hence, generic production platforms are desired. While solutions suitable for exosome manufacturing under GMP are available, most have been developed for other purposes.
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