期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 142, 期 -, 页码 16-22出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2019.06.004
关键词
Reactive oxygen species; B cell; Signaling pathway
资金
- General Program of National Natural Science Foundation of China [31770992, 81771736]
- Young Elite Scientists Sponsorship Program by CAST [YESS20160094]
Reactive oxygen species (ROS) are indispensable for determining the fate of immune cells in both physiological and pathogenic environments, thus stimulating the interest of immunologists and clinicians. B cells are essential in maintaining immune homeostasis, and studies have indicated that ROS affect the maturation, activation and differentiation of B cells by controlling the signaling molecules in various molecular pathways. In the present review, we aimed to summarize the biological properties of ROS and the mechanisms by which ROS regulate B cell signaling pathways. We propose that ROS and their mediated signal transduction can be a new approach for manipulating B cell immune functions.
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