期刊
FITOTERAPIA
卷 135, 期 -, 页码 27-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2019.03.031
关键词
Aspergillus sydowii; Sesquiterpenoid; Xanthone; Antiviral activity
资金
- National Natural Science Foundation of China [41776169, 21502204, 21772210]
- Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province [GDME-2018C010]
- Guangdong Province Public Welfare Research and Capacity Building Project [2016A020222010]
- Natural Science Foundation of Guangdong Province [2018A0303130219]
- Pearl River S&T Nova Program of Guangzhou [201710010136]
- Guangzhou Science and Technology Project [201804010462]
Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6-19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1-3, and 6-19) were evaluated for their antiviral, cytotoxic, and antibacterial activities. Among them, new compounds 2 and 3 displayed obvious selective inhibitory activities against two influenza A virus subtypes, including A/Puerto Rico/8/34 (H1N1) and A/FM-1/1/47 (H1N1), with IC50 values ranging from 2.17 +/- 1.39 to 4.70 +/- 1.11 mu M.
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