期刊
FITOTERAPIA
卷 136, 期 -, 页码 -出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2019.05.001
关键词
Cembranolide; Diterpene; Cytotoxicity; Anti-inflammatory; Lobophytum
资金
- Okinawa Institute of Science and Technology Graduate University (GIST)
Three new cembranolides (1-3) were isolated from an Okinawan soft coral, Lobophytum sp., together with the known cembranolide diterpenoids (4-9). Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS), molecular modeling, and comparison with data reported elsewhere. All compounds contain an alpha-methylene-gamma-lactone ring adjacent to a cembrane, and some of them (1, 6-8) have an epoxide ring as well. The new metabolites were evaluated for cytotoxicity against HeLa, A459, B16-F10, and RAW 264.7 cells and anti-inflammatory effect in LPS-stimulated inflammatory RAW 264.7 macrophage cells.
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