期刊
FISH & SHELLFISH IMMUNOLOGY
卷 90, 期 -, 页码 215-222出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2019.04.067
关键词
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资金
- Spanish Ministry of Science, Innovation and Universities [BIO2017-84702-R]
- Fondos Europeos de Desarrollo Regional/European Regional Development Funds
- University of Murcia
- European 7th Framework Initial Training Network FishForPharma [PITG-GA-2011-289209]
The zebrafish has unique advantages for understanding the evolution of vertebrate immunity and to model human diseases. In this review, we will firstly give an overview of the current knowledge on vertebrate innate immune receptors with special emphasis on the inflammasome and then summarize the main contribution of the zebrafish model to this field, including to the identification of novel inflammasome components and to the mechanisms involved in its activation, assembly and clearance of intracellular bacteria.
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