期刊
FASEB JOURNAL
卷 33, 期 9, 页码 9913-9928出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201900230RR
关键词
perirhinal cortex; postrhinal cortex; hippocampus; neurotransmission
资金
- Ministerio de Educacion, Cultura y Deporte [FPU13/02492]
- Ministerio de Ciencia e Innovacion [SAF2014-51851-R]
- Conselleria Educacion Generalitat Valenciana [PROMETEOII/2014/033]
- European Regional Development Fund (ERDF)
Activated microglia and increased brain IL-1 beta play a main role in cognitive impairment in much pathology. We studied the role of IL-1 beta in neuroinflammation-induced impairment of the following different types of learning and memory: novel object recognition (NOR), novel object location (NOL), spatial learning, reference memory (RM), and working memory (WM). All these processes are impaired in hyperammonemic rats. We assessed which of these types of learning and memory are restored by blocking the IL-1 receptor in vivo in hyperammonemic rats and the possible mechanisms involved. Blocking the IL-1 receptor reversed microglial activation in the hippocampus, perirhinal cortex, and prefrontal cortex but not in the postrhinal cortex. This was associated with the restoration of NOR and WM but not of tasks involving a spatial component (NOL and RM). This suggests that IL-1 beta would be involved in neuroinflammation-induced nonspatial memory impairment, whereas spatial memory impairment would be IL-1 beta-independent and would be mediated by other proinflammatory factors.-Taoro-Gonzalez, L., Cabrera-Pastor, A., Sancho-Alonso, M., Arenas, Y. M., Meseguer-Estornell, F., Balzano, T., ElMlili, N., Felipo, V. Differential role of interleukin-1 beta in neuroinflammation-induced impairment of spatial and nonspatial memory in hyperammonemic rats.
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