期刊
FASEB JOURNAL
卷 33, 期 9, 页码 10177-10192出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201900414R
关键词
rod; bystander effect; environmental enrichment; microglia; cytokines
资金
- Fondazione Roma (Rome, Italy)
- Velux Foundation Stiftung (Zurich, Switzerland)
- EU Horizon 2020 research and innovation program - Marie Sklodowska-Curie grant [674901]
- Marie Curie Actions (MSCA) [674901] Funding Source: Marie Curie Actions (MSCA)
Hallmark of retinitis pigmentosa (RP) is the primary, genetic degeneration of rods followed by secondary loss of cones, caused by still elusive biologic mechanisms. We previously shown that exposure of rd10 mutant mice, modeling autosomal recessive RP, to environmental enrichment (EE), with enhanced motor, sensorial and social stimuli, results into a sensible delay of retinal degeneration and vision loss. Searching for effectors of EE-mediated retinal protection, we performed transcriptome analysis of the retina of rd10 enriched and control mice and found that gene expression at the peaks of rod and cone degeneration is characterized by a strong inflammatory/immune response, which is however measurably lower in enrichment conditions. Treating rd10 mice with dexamethasone during the period of maximum photoreceptors death lowered retinal inflammation and caused a preservation of cones and cone-mediated vision. Our findings indicate a link between retinal inflammation and bystander cone degeneration, reinforcing the notion that cone vision in RP can be preserved using anti-inflammatory approaches.-Guadagni, V., Biagioni, M., Novelli, E., Aretini, P., Mazzanti, C. M., Strettoi, E. Rescuing cones and daylight vision in retinitis pigmentosa mice.
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