期刊
EXPERIMENTAL PARASITOLOGY
卷 201, 期 -, 页码 90-92出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2019.04.013
关键词
Pathogen box; Acanthamoeba castellanii Neff; Amoebicidal activity; Trophozoite
类别
资金
- Fondo Europeo de Desarollo Regional (FEDER) [PI18/01380]
- RICET [programme of RedesTematicas de Investigacion Cooperativa, FIS], Spanish Ministry of Science, Innovation and Universities, Madrid, Spain [RD16/0027/0001]
- Agustin de Betancourt programme
- Vicerrectorado de Internacionalizacion, Universidad de La Laguna
- RICET
Acanthamoeba are free living amoeba that have been isolated from different environments like soil, water, air dust. Moreover, they are also able to act as opportunist pathogens, mainly causing a fatal encephalitis and also keratitis in both human and animals. This study was aimed to evaluate the activity of the Medicines for Malaria Venture (MMV) compounds against the trophozoite stage of Acanthamoeba castellanii Neff. Sixteen compounds showed >= 90% inhibition of parasite growth in the initial screen (10 mu M). Those set were further evaluated to determine the inhibitor concentration that inhibit the 50% of the initial population and cytotoxicity against murine macrophages. Among the compounds included in the pathogen box, pentamidine and posaconazole were the most effective against this parasite with an of IC50 of 0.567 +/- 0.04 and 0.630 +/- 0.11, respectively.
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