期刊
EUROPEAN RADIOLOGY
卷 29, 期 12, 页码 6930-6939出版社
SPRINGER
DOI: 10.1007/s00330-019-06240-6
关键词
Renal neoplasms; Diffusion-weighted MRI; Intravoxel incoherent motion; Diffusion kurtosis imaging; Differential diagnosis
资金
- Educational Specialist Training Fund [002]
- Zhongshan Hospital, Fudan University
Objective To quantitatively compare the diagnostic values of conventional diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) in differentiating between malignant and benign renal tumors. Methods Multiple b value DWIs and DKIs were performed in 180 patients with renal tumors, which were divided into clear cell renal cell carcinoma (ccRCC), non-ccRCC, and benign renal tumor group. The apparent diffusion coefficient (ADC), true diffusivity (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), mean kurtosis (MK), and mean diffusivity (MD) maps were calculated. The diagnostic efficacy of various diffusion parameters for predicting malignant renal tumors was compared. Results The ADC, D, and MD values of ccRCCs were higher, while D*, f, and MK values were lower than those of benign renal tumors (all p<0.025). The D* and f values of non-ccRCCs were lower than those of benign renal tumors (p=0.002 and p<0.001, respectively). The difference of ADC, D, MD, and MK values between non-ccRCCs and benign renal tumors was not statistically significant (p>0.05). The ADC, D, MD, and f values of ccRCCs were higher, while MK values were lower than those of non-ccRCCs (all p<0.001). The AUC values of ADC, D, D*, f, MK, and MD were 0.849, 0.891, 0.708, 0.656, 0.862, and 0.838 for differentiating ccRCCs from benign renal tumors, respectively. The AUC values of D* and f were 0.772 and 0.866 for discrimination between non-ccRCCs and benign renal tumors, respectively. Conclusion IVIM parameters are the best, while DWI and DKI parameters have similar performance in differentiating malignant and benign renal tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据