期刊
EUROPEAN POLYMER JOURNAL
卷 116, 期 -, 页码 311-320出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2019.04.016
关键词
Chitosan; Poly(2-oxazoline); Films; Miscibility; Mucoadhesion; Ocular drug delivery
资金
- Ministry of Education and Science of the Republic of Kazakhstan [AP05133221]
- British Council Newton - Al-Farabi Partnership Programme, the Researcher Links Post-Doctoral Mobility [216046068]
Polymeric films were prepared based on chitosan and its blends with poly(2-ethyl-2-oxazoline) by casting from aqueous solutions. These materials were characterised using a number of physicochemical techniques, including Fourier-transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, wide angle x-ray diffraction, tensile testing and scanning electron microscopy. All these studies indicate that there is a weak intermacromolecular hydrogen bonding between these polymers, which facilitates their complete miscibility in solid state. These films were formulated with sodium fluorescein as a model drug and were evaluated for their potential application in ocular drug delivery both in vitro and in vivo. It was established that the films are biocompatible and mucoadhesive; they are capable of providing a sustained drug release when administered topically on the cornea.
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