期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 852, 期 -, 页码 244-253出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2019.04.001
关键词
MDR; Autophagy; Natural products
资金
- Mashhad University of Medical Sciences
Multiple drug resistance (MDR) often occurs after prolonged chemotherapy, leading to refractory tumor and cancer recurrence. Autophagy as a primarily process during starvation or stress has a bipolar nature in cancer. It can cause MDR to become more difficult or make resistant cancer cells more susceptible to chemotherapeutic agents. A number of natural products have been introduced to drug discovery for many years. Some of these compounds have been shown to reverse drug resistance by different regulatory mechanisms. In this review, the focus is on the role of medicinal plants in the MDR phenomenon, primarily through the autophagy process.
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