期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 173, 期 -, 页码 274-281出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.04.043
关键词
1,2,4-triazole; Hybrid compounds; Antibacterial activity; Structure-activity relationship
资金
- National Natural Science Foundation of China [81830052, 81530053]
- Shanghai Key Laboratory of Molecular Imaging [18DZ2260400]
Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. More effective antibacterial candidates might be obtained by the hybridization of 1,2,4-triazole with other antibacterial pharmacophores. This review summarizes the recent advances of 1,2,4-triazole derivatives as potential antibacterial compounds, and the structure-activity relationship is also discussed. (C) 2019 Elsevier Masson SAS. All rights reserved.
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