4.6 Article

Ferrocene-substituted 3,3′-diindolylmethanes with improved anticancer activity

期刊

APPLIED ORGANOMETALLIC CHEMISTRY
卷 30, 期 6, 页码 441-445

出版社

WILEY-BLACKWELL
DOI: 10.1002/aoc.3452

关键词

Indole; ferrocene; DIM; anticancer drugs; drug resistance

资金

  1. Deutsche Forschungsgemeinschaft [Scho 402/12-1]

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A series of ferrocene-substituted derivatives (2a-g) of the known drug 3,3'-diindolylmethane (DIM) were prepared and tested for their in vitro antitumor activity. The derivatives 2a (featuring indole moiety), 2b (featuring 2-methylindole moiety) and 2f (featuring 5-nitroindole moiety) were growth-inhibiting in vitro at lower concentrations than DIM in various tumor cells including pancreas cancer (BcPC-3), three DIM-resistant cancer cell lines (518A2, KB-V1/Vbl, HT-29), triple-negative breast cancer (MDA-MB-231) and prostate cancer (PC-3). Derivatives 2a, 2b and 2f were the most active compounds of this series, qualifying as drug candidates for various cancer diseases. Copyright (C) 2016 John Wiley & Sons, Ltd.

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