期刊
ENVIRONMENT INTERNATIONAL
卷 128, 期 -, 页码 103-108出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2019.04.036
关键词
Air pollution; Particulate matter; Blood pressure; Hypertension; Children; Adolescents
资金
- Research Special Fund for Public Welfare Industry of Health of the Ministry of Health of China [201202010]
- Excellent Talents Fund Program of Peking University Health Science Center [BMU2017YJ002]
- Career Development Fellowship of Australian National Health and Medical Research Council [APP1107107, APP1163693]
- Early Career Fellowship of Australian National Health and Medical Research Council [APP1109193]
Background: Air pollution has been associated with elevated blood pressure in adults. However, epidemiological evidence from children and adolescents is limited. We investigated the associations between long-term exposure to particulate matter (PM) air pollution and blood pressure in a large population of children and adolescents. Methods: A cross-sectional analysis was performed in a nationally representative sample consisting of 43,745 children and adolescents aged 7 to 18 years in seven provinces in China. Exposure to ambient fine particles (PM2.5) and thoracic particles (PM10) was estimated using spatiotemporal models based on satellite remote sensing, meteorological data and land use information. Mixed-effects (two-level) linear and logistic regression models were used to investigate the associations between PM exposure and systolic blood pressure (SBP), diastolic blood pressure (DBP) and hypertension. Results: After adjustment for a wide range of covariates, every 10 mu g/m(3) increment in PM2.5 and PM10 concentration was associated with 1.46 [95% confidence interval (CI): 0.05, 2.88] and 1.36 (95% CI: 0.34, 2.39) mmHg increases in SBP, respectively. PM10 was also associated with higher prevalence of hypertension [odds ratio per 10 mu g/m(3) increment: 1.45 (95% CI: 1.07, 1.95)]. Conclusions: Long-term exposure to ambient PM air pollution was associated with increased blood pressure and higher prevalence of hypertension in children and adolescents. Our findings support air pollution reduction strategies as a prevention measure of childhood hypertension, a well-recognized risk factor of future cardiovascular health.
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