期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 100, 期 15, 页码 6585-6599出版社
SPRINGER
DOI: 10.1007/s00253-016-7670-x
关键词
Baeyer-Villiger monooxygenases; Cascade reactions; Whole-cell immobilization; Polyelectrolyte complex capsules; Asymmetric synthesis; Biocatalysis
资金
- Slovak Grant Agency for Science VEGA [2/0090/16]
- Slovak Research and Development Agency [APVV-15-0227]
- Research & Development Operational Programme - ERDF [26240220079]
- FWF [I723-N17, P24483-B20]
- TU Wien (ABC-TOP Anschubfinanzierung)
- COST action systems biocatalysis [WG2]
Baeyer-Villiger monooxygenases ( BVMOs) are a very well-known and intensively studied class of flavin-dependent enzymes. Their substrate promiscuity, high chemo-, regio-, and enantioselectivity are prerequisites for the use in synthetic chemistry and should pave the way for successful industrial processes. Nonetheless, only a very limited number of industrial relevant transformations are known, mainly due to the lack of BVMOs stability and cofactor dependency. In this review, we focus on novel BVMO-mediated transformations, BVMOs in cascade type reactions, potential industrial applications, and how limitations have been tackled by the community. Special attention will be put on whole-cell immobilization strategies. We emphasize to bridge recent developments in fundamental research to industrial applications.
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