期刊
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
卷 14, 期 5, 页码 931-965出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10237-015-0662-4
关键词
Brain; Solid mechanics; Fluid mechanics; Electrochemistry; Electromechanics; Traumatic brain injury
资金
- Wolfson/Royal Society
- Reintegration Grant under EC Framework VII
- European Unions Seventh Framework Programme, ERC [306587]
- NSERC
- NSF CAREER award [CMMI 0952021]
- NIH [U01 HL119578]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [0952021] Funding Source: National Science Foundation
The human brain is the continuous subject of extensive investigation aimed at understanding its behavior and function. Despite a clear evidence that mechanical factors play an important role in regulating brain activity, current research efforts focus mainly on the biochemical or electrophysiological activity of the brain. Here, we show that classical mechanical concepts including deformations, stretch, strain, strain rate, pressure, and stress play a crucial role in modulating both brain form and brain function. This opinion piece synthesizes expertise in applied mathematics, solid and fluid mechanics, biomechanics, experimentation, material sciences, neuropathology, and neurosurgery to address today's open questions at the forefront of neuromechanics. We critically review the current literature and discuss challenges related to neurodevelopment, cerebral edema, lissencephaly, polymicrogyria, hydrocephaly, craniectomy, spinal cord injury, tumor growth, traumatic brain injury, and shaken baby syndrome. The multi-disciplinary analysis of these various phenomena and pathologies presents new opportunities and suggests that mechanical modeling is a central tool to bridge the scales by synthesizing information from the molecular via the cellular and tissue all the way to the organ level.
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