期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 152, 期 -, 页码 111-118出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2019.05.015
关键词
Child; Insulin pump therapy; Intermittently scanned continuous glucose monitoring; Real time continuous glucose monitoring; Type 1 diabetes
Aims: In 2016 intermittently scanned continuous glucose monitoring (isCGM) became the first reimbursed CGM system in Belgium. Many children with type 1 diabetes (T1D) treated with multiple daily injections as well as with continuous subcutaneous insulin infusion (CSII) switched from self-monitoring of blood glucose to is CGM to monitor their treatment. In 2017 the Enlite (R) real-time CGM (rtCGM) system was reimbursed enabling its use with the Minimed (R) 640G insulin pump with integrated SmartGuard technology. In this study we compared the metabolic control during CSII with isCGM with that during rtCGM. Patient's satisfaction and side effects of the rtCGM system were also evaluated. Methods: 20 children with T1D, aged 5-16 years, were included. Metabolic control during the last month of isCGM use was compared to that during the 3rd and 6th month of rtCGM. Results: Three patients stopped early rtCGM mainly due to calibration burden. The HbA1c level and the mean glucose value in the other patients did not change after switching to the rtCGM system. Glucose variability was smaller (46.2% vs 38.4% and 36.4%, p = 0.000). Time in hypoglycemia (<70 mg/dl) was lower (7.4% vs 1.6% and 1.5%, p = 0.000). The main patient inconvenience was the sensor calibration. Conclusions: Our data show that during Enlite (R) rtCGM with the Minimed (R) 640G pump system glucose variability was smaller and the patients spent less time in hypoglycemia than during isCGM. The need for timely calibrations is considered as the main drawback of the system. (C) 2019 Elsevier B.V. All rights reserved.
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