期刊
DEVELOPMENT
卷 146, 期 16, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.175158
关键词
Abdominal-B; Doublesex; Drosophila; Neuroblast; Apoptosis; Sexual dimorphism
资金
- Wellcome Trust DBT India Alliance Intermediate Fellowship [500171/Z/09/Z]
- Department of Biotechnology, India [BT/PR26385/MED/122/110/2017, BT/PR27455/BRB/10/1647/2018]
- Department of Science and Technology India [EMR/2016/003775]
- Indian Council of Medical Research [3/1/3/JRF-2011/HRD-59 (42219)]
- University Grants Commission India [22/06/2014(i)EU-V, 2061430472]
- Centre for DNA Fingerprinting and Diagnostics core funds
Highly conserved DM domain-containing transcription factors (Doublesex/MAB-3/DMRT1) are responsible for generating sexually dimorphic features. In the Drosophila central nervous system, a set of Doublesex (Dsx)-expressing neuroblasts undergo apoptosis in females whereas their male counterparts proliferate and give rise to serotonergic neurons crucial for adult mating behaviour. Our study demonstrates that the female-specific isoform of Dsx collaborates with Hox gene Abdominal-B (Abd-B) to bring about this apoptosis. Biochemical results suggest that proteins AbdB and Dsx interact through their highly conserved homeodomain and DM domain, respectively. This interaction is translated into a cooperative binding of the two proteins on the apoptotic enhancer in the case of females but not in the case of males, resulting in female-specific activation of apoptotic genes. The capacity of AbdB to use the sex-specific isoform of Dsx as a cofactor underlines the possibility that these two classes of protein are capable of cooperating in selection and regulation of target genes in a tissue- and sex-specific manner. We propose that this interaction could be a common theme in generating sexual dimorphism in different tissues across different species.
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