期刊
CURRENT PHARMACEUTICAL DESIGN
卷 25, 期 15, 页码 1694-1706出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612825666190701144709
关键词
Selenium; biological materials; longevity; age-related diseases; oxidative stress; Se-supplementation
资金
- LabEx [ParaFrapANR-11-LABX-0024]
Background: Selenium (Se) is a trace element active in selenoproteins, which can regulate oxidative stress. It is generally perceived as an import factor for maintaining health in the elderly. Methods: The goal of this review is to discuss selenium concentration in biological samples, primarily serum or plasma, as a function of age and its relation with longevity. The elemental level in various age-related diseases is reviewed. Conclusion: Highest selenium values were observed in healthy adults, while in an elderly population significantly lower concentrations were reported. Variables responsible for contradictory findings are mentioned. Risk and benefits of Se-supplementation still remain under debate.
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