期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 20, 期 11, 页码 945-954出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573407215666190628145902
关键词
Quercetin; microparticle; fast-release; anti-tumor activity; lung cancer cells; microparticles
资金
- National Natural Science Foundation of China [31600631]
- Natural Science Foundation of Shanxi Province, China [2015021047]
- Science-Technology Innovation Foundation of the Higher Education Institutions of Shanxi Province, China [2016116]
Background: Novel quercetin-loaded microparticles (QM) were fabricated using coaxial electrospraying, characterized for surface morphology and release profile, and evaluated for antitumor activity in vitro. Methods: QM exhibited an average diameter of 1.69 +/- 1.13 mm, which was an appropriate size suitable for respiratory delivery. X-ray diffraction patterns showed that the components in QM existed in an amorphous physical form, leading to favorable interactions between the drug (quercetin), the polymer matrix (polyvinylpyrrolidone, PVP) and other excipients (sodium dodecyl sulfate and sucralose). Results: QM performed much faster release rate compared with free quercetin powder (Q) in vitro. Furthermore, QM also showed more potent inhibitory effects on A549 cell growth with reduced cell viability, decreased cell migration and induced more G0/G1 phase cell cycle arrest than Q. Conclusion: Thus, the quercetin loaded microparticles exhibited more potent inhibitory effects than free quercetin on A549 cell. The increased antitumor activity could be attributed to the enhanced accumulation of quercetin in the A549 cells with the QM. However, further studies are necessary to elucidate the exact mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据