期刊
CURRENT OPINION IN IMMUNOLOGY
卷 58, 期 -, 页码 98-103出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2019.04.014
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资金
- National Institutes of Health [DP2 CA225212]
- Josie Robertson Young Investigator Award
- NISK Cancer Center [P30 CA008748]
- V Foundation for Cancer Research
- Scrodino Family Adventure Alice Fund
CD8 T cell differentiation is a tightly regulated process generating effector and memory T cells over the course of acute infections. In cancer and chronic infection, this differentiation program is derailed, and antigen-specific CD8 T cells differentiate to a hyporesponsive state generally referred to as T cell exhaustion. Here, we review recent findings on heterogeneity of tumor-specific T cells and exhausted T cells during chronic infections, discussing distinct differentiation state dynamics, fate choices, and functional states. Delineating the regulatory mechanisms defining distinct T cell states and determining the requirements for therapeutic reprogramming of these states will provide needed insights for the design of effective immunotherapies for the treatment of cancer and chronic infections.
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