期刊
COMPUTERS IN BIOLOGY AND MEDICINE
卷 109, 期 -, 页码 235-241出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2019.04.041
关键词
Foetal heart rate; Acidaemia; Power spectral analysis; Base excess; Variability
类别
资金
- North Portugal Regional Operational Programme (NORTE2020), under the PORTUGAL 2020 Partnership Agreement
- European Regional Development Fund [NORTE-01-0145-FEDER-000016]
- doctorate scholarship from the Clinical Research and Health Services Program
- European Social Fund under the Portuguese Norte 2020 research and innovation program [Norte-08-5369-FSE-000063]
- Postdoc Grant [NanoSTIMA-WP4.1.1-D.]
A computational analysis of physiological systems has been used to support the understanding of how these systems work, and in the case of foetal heart rate, many different approaches have been developed in the last decades. Our objective was to apply a new method of classification, which is based on spectral analysis, in foetal heart rate (FHR) traces to predict foetal acidosis diagnosed with umbilical arterial blood pH <= 7.05. Fast Fourier transform was applied to a real database for the classification approach. To evaluate the models, sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve were used. Sensitivity equal to 1, specificity equal to 0.85 and an area under the ROC curve of 0.94 were found. In addition, when the definition of metabolic acidosis of umbilical arterial blood pH <= 7.05 and base excess <= -10 mmol/L was used, the proposed methodology obtained sensitivity = 1, specificity = 0.97 and area under the ROC curve = 0.98. The proposed methodology relies exclusively on the spectral frequency decomposition of the FHR signal. After further successful validation in more datasets, this approach can be incorporated easily in clinical practice due to its simple implementation. Likewise, the incorporation of this novel technique in an intrapartum monitoring station should be straightforward, thus enabling the assistance of labour professionals in the anticipated detection of acidaemia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据