期刊
BIOMATERIALS
卷 55, 期 -, 页码 12-23出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.03.034
关键词
POSS; Amphiphilic micelles; Doxorubicin; P53; Co-delivery; Cancer therapy
资金
- National Natural Science Funds for Distinguished Young Scholar [51325305]
- Technology Major Project of China [2012ZX10004801-003-007, 2012AA022603]
In this work, a star-shaped polymer consisting of a cationic poly[2-(dimethylamino) ethyl methacrylate] (PDMAEMA) shell and a zwitterionic poly[N-(3-(methacryloylamino) propyl)-N,N-dimethyl-N-(3-sulfopropyl) ammonium hydroxide] (PMPD) corona was grafted from a polyhedral oligomeric silses-quioxanes (POSS)-based initiator via atomic transfer radical polymerization (ATRP). The reported star-shaped polymer could form stable micelles in aqueous solutions even in the presence of serum. In addition, anti-cancer drug doxorubicin and tumor-suppressing p53 gene were loaded in the process of micelle formation. The formed polyplex was biocompatible and highly efficient for both drug and gene delivery. Furthermore, the polyplex was able to cause a high apoptotic rate of tumor cells both in vitro and in vivo. This combination delivery strategy offers a promising method for cancer therapy and can be used for further clinical applications. (C) 2015 Elsevier Ltd. All rights reserved.
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