期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
卷 220, 期 -, 页码 1-8出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2019.02.010
关键词
Ruditapes philippinarum; Mercury; Benzo[a]pyrene; Physiological and biochemical biomarkers; IBR value
资金
- National Natural Science Foundation of China [41761134052, 41676147]
- Qingdao National Laboratory for Marine Science and Technology [QNLM201707]
- China Postdoctoral Science Foundation [2018M642728]
- Modern Agroindustry Technology Research System [CARS-49]
Physiological and biochemical responses in bivalves exposed to pollutants have proved a valuable tool to assess the health of organisms in aquatic ecosystems. The single and combined effects of mercury (Hg2+, 2 and 10 mu g/L) and benzo[a] pyrene (BaP, 3 mu g/L) on physiological and biochemical biomarkers in Manila clam, Ruditapes philippinarum were evaluated. Results showed that significant higher oxygen consumption (OR) and ammonia-N excretion rates (NR) together with significant lower ingestion rates (IR) were observed for the 10 mu g/L Hg2+ or 3 mu g/L BaP treatments compared to controls (P < 0.05). However, clam NR decreased significantly in response to the binary mixtures of 10 mu g/L Hg2+ and 3 mu g/L BaP (P < 0.05). Moreover, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferases (GSTs), glutathione (GSH), acetylcholinesterase (AChE) and malondialdehyde (MDA) in the hepatopancreas of clams were induced substantially, whereas glycogen (GLY) contents were suppressed dramatically after Hg2+ and BaP exposure. Additionally, the integrated biomarker response (IBR) values measured showed significant increases in combination treatments and they were much higher than that in the Hg2+ treatment. This study will provide further information on the defense mechanism in the Manila clam after exposure to marine pollutants and may help evaluate the quality of the aquatic environment.
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