期刊
BIOMATERIALS
卷 66, 期 -, 页码 21-28出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.06.043
关键词
Nano-graphene; Radiotherapy; Combined therapy; Radio labeling; Gamma imaging
资金
- National Basic Research Program of China (973 Program) [2014CB931900, 2012CB932601]
- National Science Foundation of China [81471716, 81302383, 31400861, 21207164, 51222203]
- National Natural Science Foundation of Jiangsu Province [BK20140320, BK20130005]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Nano-graphene and its derivatives have attracted great attention in biomedicine, including their applications in cancer theranostics. In this work, we develop 131I labeled, polyethylene glycol (PEG) coated reduced nano-graphene oxide (RGO), obtaining 131I-RGO-PEG for nuclear imaging guided combined radiotherapy and photothermal therapy of cancer. Compared with free 131I, 131IRGO- PEG exhibits enhanced cellular uptake and thus improved radio-therapeutic efficacy against cancer cells. As revealed by gamma imaging, efficient tumor accumulation of 131I-RGO-PEG is observed after its intravenous injection. While RGO exhibits strong near-infrared (NIR) absorbance and could induce effective photothermal heating of tumor under NIR light irradiation, 131I is able to emit high-energy X-ray to induce cancer killing as the result of radio ionization effect. By utilizing the combined photothermal therapy and radiotherapy, both of which are delivered by a single agent 131IRGO- PEG, effective elimination of tumors is achieved in our animal tumor model experiments. Toxicology studies further indicate that 131I-RGO-PEG induces no appreciable toxicity to mice at the treatment dose. Our work demonstrates the great promise of combing nuclear medicine and photothermal therapy as a novel therapeutic strategy to realize synergistic efficacy in cancer treatment. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.
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