期刊
BIOMATERIALS
卷 37, 期 -, 页码 312-319出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.10.039
关键词
Intraperitoneal chemotherapy; Drug delivery; Hyaluronic acid; Platinum; Ovarian cancer; Empty carriers
资金
- NSF [DMR-1056997]
- NIH [R01 EB017791, P30 CA023168]
- Lilly Endowment, Inc.
- Mildred Elizabeth Edmundson Research Grant
- Purdue University Center for Cancer Research Small Grants Program
- Purdue University
- Purdue Research Foundation Research Grant
- Indiana CTSI Core Pilot Award
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1056997] Funding Source: National Science Foundation
Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of solid carcinomas confined within the peritoneal cavity, with potential benefits in locoregional and systemic management of residual tumors. In this study, we intended to increase local retention of platinum in the peritoneal cavity over a prolonged period of time using a nanoparticle form of platinum and an in-situ crosslinkable hyaluronic acid gel. Hyaluronic acid was chosen as a carrier due to the biocompatibility and biodegradability. We confirmed a sustained release of platinum from the nanoparticles (PtNPs) and nanoparticle/gel hybrid (PtNP/gel), receptor-mediated endocytosis of PtNPs, and retention of the gel in the peritoneal cavity over 4 weeks: conditions desirable for a prolonged local delivery of platinum. However, PtNPs and PtNP/gel did not show a greater anti-tumor efficacy than CDDP solution administered at the same dose but rather caused a slight increase in tumor burdens at later time points, which suggests a potential involvement of empty carriers and degradation products the growth of residual tumors: This study alerts that although several materials considered biocompatible and safe are used as drug carriers, they may have unwanted biological effects on the residual targets once the drug is exhausted; therefore, more attention should be paid to the selection of drug carriers. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据