期刊
CLINICAL INFECTIOUS DISEASES
卷 70, 期 4, 页码 676-679出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciz507
关键词
immune reconstitution; bone marrow transplantation; primary immunodeficiency; Mycobacterium avium
资金
- Intramural Research Program of the National Institute of Allergy and Infectious Disease, National Institutes of Health
- National Cancer Institute, National Institutes of Health
- US federal funds from the National Cancer Institute, National Institutes of Health
- NATIONAL CANCER INSTITUTE [ZIABC011659] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000646, ZIAAI001247, ZIAAI000647, ZIAAI001121] Funding Source: NIH RePORTER
Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.
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