期刊
CHEMOSPHERE
卷 227, 期 -, 页码 237-246出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2019.04.057
关键词
Polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans; Dioxins; Foundry plant; Waste incineration; Oxidative stress
资金
- National Public Beneficial Scientific Research on Environmental Protection from Ministry of Environmental Protection of the People's Republic of China [201309046]
- Fundamental Research Funds for the Central Universities [HUST 2016JCTD116]
Polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans (PCDD/Fs) have been reported to induce reactive oxygen species and oxidative stress, but the dose-response relationships have not been explored in molecular epidemiological studies. In this study, a total of 602 participants were recruited, comprising of 215 foundry workers, 171 incineration workers and 216 residents living more than 5 km away from the plants as the reference group. Individual PCDD/Fs exposures were estimated according to PCDD/Fs levels of working and living ambient air and daily foods. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-iso-prostaglandin-F2 alpha (8-isoPGF2 alpha) were determined to reflect oxidatively generated damage to DNA and lipid. Generalized linear models were used to access the associations between PCDD/Fs exposure and oxidative stress biomarkers. We found that PCDD/Fs exposure and urinary oxidative stress biomarkers of workers were all higher than those of the reference group. Significantly positive exposure-response relationships between individual PCDD/Fs exposures and urinary 8-oxodG and 8-iso-PGF2 alpha were found. Each 1-unit increase in In-transformed levels of PCDD/Fs exposure generated a 0.78 nmol/mmol creatinine increase in In-transformed 8-oxodG and a 0.50 ng/mmol creatinine increase in In-transformed 8-isoPGF2 alpha in foundry workers, a 0.49 nmol/mmol creatinine increase in In-transformed 8-oxodG and a 0.26 ng/mmol creatinine increase in ln-transformed 8-isoPGF2 alpha in incineration workers, compared with the reference group. And such associations were not modified by tobacco use. Our findings could help to understand the dose-response relationships between PCDD/Fs and oxidatively generated damage to DNA and lipid, and provide an epidemiologic basis for conducting research on the carcinogenesis and other toxicity mechanisms of PCDD/Fs. (C) 2019 Elsevier Ltd. All rights reserved.
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