期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 14, 期 12, 页码 2162-2168出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201900416
关键词
carbon dots; photodynamic therapy; imaging; natural products
资金
- National Natural Science Foundation of China [61720106014, 51572269]
- International Partnership Program of Chinese Academy of Sciences [GJHZ1723]
- Instrument Developing Project of the Chinese Academy of Sciences [YJKYYQ20170015]
Carbon dots (CDs), a kind of phototheranostic agent with the capability of simultaneous bioimaging and phototherapy [i.e., photodynamic therapy (PDT) or photothermal therapy (PTT)], have received considerable attention because of their remarkable properties, including flexibility for surface modification, high biocompatibility, low toxicity and photo-induced activity for malignant tumor cells. Among numerous carbon sources, it has been found that natural biomass are good candidates for the preparation of CD phototheranostic agents. In this study, pheophytin, a type of Mg-free chlorophyll derivative and also a natural product with low toxicity, was used as a raw carbon source for the synthesis of CDs by using a microwave method. The obtained hydrophobic CDs exhibited a maximum near-infrared (NIR) emission peak at approximately 680 nm, and high singlet oxygen (O-1(2)) generation with a quantum yield of 0.62. The self-assembled CDs from the as-prepared CDs with DSPE-mPEG2000 retained efficient O-1(2) generation. The obtained carbon dot assembly was not only an efficient fluorescence (FL) imaging agent but also a smart PDT agent. Our studies indicated that the obtained hydrophilic CD assembly holds great potential as a new phototheranostic agent for cancer therapy. This work provides a new route for synthesis of CDs and proposes a readily available candidate for tumor treatment.
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