期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 41, 页码 9634-9638出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201902296
关键词
AIE; azobenzene; fluorescence probe; hypoxia; self-assembly
资金
- National Key Research and Development Program of China [2017YFA0701303, 2018YFA0209700]
- National Natural Science Foundation of China [51873097, 21674058]
A hypoxia-responsive fluorescence probe of amphiphilic PEGylated azobenzene caged tetraphenylethene (TPE) for tumor cell imaging is reported; it possesses excellent solubility in aqueous medium due to the easy formation of micelles by self-assembly. The fluorescence resonance energy transfer (FRET) process ensures that the fluorescence of the azobenene caged AIE fluorogen is quenched efficiently. When cultured with tumor cells, the azo-bond is reduced under hypoxia conditions and the fluorescence of AIE fluorogen recovers dramatically. Besides using UV light, NIR light can also be used as the excited light resource to generate the fluorescence due to the two-photon fluorescence imaging process.
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