期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 47, 页码 11031-11035出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201902878
关键词
amino acids; hyperpolarization; nanoparticles; NMR spectroscopy; PHIP
资金
- National Science Foundation (NSF) [CHE-1153159, CHE-1508707, CHE-1048804]
- Arnold and Mabel Beckman Foundation
- Jonsson Comprehensive Cancer Center Foundation at UCLA
- Max Planck Society
- Max Planck Institute for Biophysical Chemistry
- EPSRC [EP/P009980/1] Funding Source: UKRI
NMR offers many possibilities in chemical analysis, structural investigations, and medical diagnostics. Although it is broadly used, one of NMR spectroscopies main drawbacks is low sensitivity. Hyperpolarization techniques enhance NMR signals by more than four orders of magnitude allowing the design of new contrast agents. Parahydrogen induced polarization that utilizes the para-hydrogen's singlet state to create enhanced signals is of particular interest since it allows to produce molecular imaging agents within seconds. Herein, we present a strategy for signal enhancement of the carbonyl C-13 in amino acids by using parahydrogen, as demonstrated for glycine and alanine. Importantly, the hyperpolarization step is carried out in water and chemically unmodified canonical amino acids are obtained. Our approach thus offers a high degree of biocompatibility, which is crucial for further application. The rapid sample hyperpolarization (within seconds) may enable the continuous production of biologically useful probes, such as metabolic contrast agents or probes for structural biology.
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