Anti-Ache Benzylbenzofuran Derivatives from Silene conoidea

A new benzylbenzofuran, named 5 ',7-dihydroxy-6-propenyl-2-(11 ',12 '-dimethylpyran)-benzylbenzofuran (1), and seven known benzylbenzofuran derivatives (2-8) were isolated from Silene conoidea L. for the first time. The structures of compounds 1-8 were identified by their spectral data and reference data. Compounds 1-8 were evaluated for anti-acetylcholinesterase (AChE) activities for the first time. Compounds 1, 2, 5, and 6 showed anti-AChE activities with IC50 values ranging from 12.55-85.43 mu M.