期刊
CHEMICAL ENGINEERING SCIENCE
卷 200, 期 -, 页码 113-126出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2019.01.044
关键词
Phytochemicals; Skin inflammation; Lipid nanocarriers; Indomethacin; Willow bark extract
资金
- Ministry National Education, CNCS-UEFISCDI [PCE_PN-II-ID-PCE-2012-4-0111]
Current research is focused toward the development of a new approach based on efficient bioactive lipid nanocarriers (BLN) in order to obtain enhanced benefit to risk ratios of natural and synthetic actives. For this purpose, the bioactivities of several BLN (prepared with raspberry oil, Rso, and rice bran oil, Rbo) containing a natural extract (willow bark extract, Wbe) or a blend of Wbe and the synthetic anti-inflammatory drug indomethacin (Ind) have been comparatively analysed. BLN exhibited homogeneity regarding the particle size (diameters less than 140 nm), excellent physical stability (negative surface charge of -40 and -48 mV) and high encapsulation efficiency (89 to 91% for salicin from Wbe and 65 to 72.5% for Ind). The association of Wbe together with Ind co-loaded BLN resulted in a noticeable amplification of the antioxidant activity (the scavenging of free oxygen radicals exceeds 90%), a protective effect on L929 cells (low apoptosis values of 11.6 and 15.9%) and a significant ability to reduce the TNF-alpha and IL-6 inflammatory marker levels. The in vitro release, achieved on BLN-Wbe-Ind based-hydrogels, has revealed a gradual release of both kinds of actives. BLN may represent a valuable strategy for overcoming the side effects of synthetic drugs while treating inflammation-related skin disorders. (C) 2019 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据