期刊
BIOMATERIALS
卷 61, 期 -, 页码 95-102出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.05.018
关键词
Au/Fe/Au plasmonic nanoparticles; Magnetic targeting; Dual in vivo imaging; Chemo-photothermal treatment; Rheumatoid arthritis
资金
- Korean Health Technology R&D Project, Ministry of Health Welfare [A110905]
- Ministry of Science, KT and Future Planning through the National Research Foundation (NRF) of Korea [2011-0017486, 2012R1A4A1029061, 2013R1A1A3A04009309]
We have developed methotrexate (MTX)-loaded poly(lactic-co-glycolic acid, PLGA) gold (Au)/iron (Fe)/gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid (RGD), which can be applied for magnetic targeted chemo-photothermal treatment, and in vivo multimodal imaging of rheumatoid arthritis (RA). Upon near-infrared (NIR) irradiation, local heat is generated at the inflammation region due to the NIR resonance of Au half-shells and MIX release from PLGA nanoparticles is accelerated. The Fe half-shell layer embedded between the Au half-shell layers enables in vivo T-2-magnetic resonance (MR) imaging in addition to NIR absorbance imaging. Furthermore, the delivery of the nanoparticles to the inflammation region in collagen-induced arthritic (CIA) mice, and their retention can be enhanced under external magnetic field. When combined with consecutive NIR irradiation and external magnetic field application, these nanoparticles provide enhanced therapeutic effects with an MIX dosages of only 0.05% dosage compared to free MTX therapy for the treatment of RA. (C) 2015 Elsevier Ltd. All rights reserved.
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