期刊
CHEMICAL ENGINEERING & TECHNOLOGY
卷 42, 期 10, 页码 2085-2094出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ceat.201900115
关键词
Downstream processing; Dynamic light scattering; Flow chemistry; Microreaction technology; Nanoparticles
资金
- program Wissen schafft Zukunft''
- Stiftung Rheinland-Pfalz fur Innovation of the Ministerium fur Wissenschaft, Weiterbildung und Kultur Rheinland Pfalz [961 - 52 123-7/40 (9), 961-386261/1224]
- Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V.
Nanoparticular materials have a great potential in various fields including technical and biomedical applications; to meet the specific requirements, a good control over the particle characteristics is mandatory. Addressing this, a modular system for the automated and continuous synthesis, workup, and analysis of a broad range of nanoparticles was developed. Application examples of inorganic (silica) and organic (polymersomes, niosomes) nanoparticles demonstrate the versatility of the production platform. Modules for downstream processing via a falling-film microreactor or tangential flow filtration are presented. The hydrodynamic size as a key parameter is acquired in real time, with an inline dynamic light scattering device. All modules are controlled and operated by a process control system.
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