期刊
CHEMBIOCHEM
卷 20, 期 21, 页码 2793-2799出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201900309
关键词
conjugated polymers; imaging agents; nanoparticles; photothermal conversion; second near-infrared
资金
- the China Postdoctoral Science Foundation [2017M612192] Funding Source: Medline
- the National Natural Science Foundation of China [21807062, 21675091, 21874078, 21574072] Funding Source: Medline
- the Shandong Provincial Natural Science Foundation [ZR2018BB014] Funding Source: Medline
- the Source Innovation Project of Qingdao [171183jch] Funding Source: Medline
- Major Science and Technology Innovation Project of Shandong Province [2018CXGC1407] Funding Source: Medline
- the Taishan Young Scholar Program of Shandong Province [tsqn20161027] Funding Source: Medline
- the People's Livelihood Science and Technology Project of Qingdao [166257nsh, 173378nsh] Funding Source: Medline
- the First Class Discipline Project of Shandong Province. [2016001] Funding Source: Medline
- the Innovation Leader Project of Qingdao [168325zhc] Funding Source: Medline
- the Key Research and Development Project of Shandong Province [2016GGX102039, 2017GGX20111, 2016GGX102028] Funding Source: Medline
- the Project of Shandong Province Higher Educational Science and Technology Program [J15LC20] Funding Source: Medline
Fluorescence imaging (FI) and photoacoustic imaging (PA) play important roles in the real-time assessment of cell-based therapies. However, the limitations of conventional organic fluorescence contrast agents and the narrow range of the emission wavelength in the first near-infrared (NIR-I) window (750-900 nm) hamper applications of fluorescence imaging in living subjects. Herein, we report the design and synthesis of a short-wave infrared FI contrast agent and PA contrast agent based on a conjugated polymer-poly{2,5-bis[(5-thiophen-2-yl)methylene]-3,6-bis(2-octyldodecyl)-2,5-dihydropyrazine}-and its use to construct multifunctional nanoparticles to simplify photothermal therapy.
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